Author

E. Scudese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:mouse· 5 Approach:experimental assay· 4 Assay:electronic health records· 3 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

K. Neikirk· 6 shared Z. Vue· 6 shared A. Crabtree· 5 shared A. Hinton· 5 shared E. Garza-Lopez· 5 shared L. Vang· 5 shared M. Mungai· 5 shared A. G. Marshall· 4 shared

Activity by Year

2022-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiophysics

K. Neikirk

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

E. Scudese, Z. Vue, P. Katti, A. Marshall, M. Demirci, L. Vang, E. Garza Lopez, K. Neikirk, H. Le, D. Stephens, D. D. Hall, R. Rostami, T. Rodman, K. Kabugi, J.-q. Shao, , A. Hinton

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

bioRxiv · Nov 13, 2023Biophysics

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

A. Crabtree, K. Neikirk, J. Pinette, A. Whiteside, B. Shao, J. McKenzie, Z. Vue, L. Vang, H. Le, M. Demirci, T. Ahmad, T. C. Owens, A. Oliver, F. Zeleke, H. K. Beasley, , A. Hinton

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

bioRxiv · Sep 23, 2023Biophysics

Methods to Utilize Pulse Wave Velocity to Measure Alterations in Cerebral and Cardiovascular Parameters

A. G. Marshall, K. Neikirk, B. Shao, A. Crabtree, Z. Vue, H. K. Beasley, E. Garza-Lopez, E. Scudese, C. N. Wanjalla, A. Kirabo, C. Albritton, S. Jamison, M. Demirci, S. Murray, A. Cooper, , A. K. Reddy

This paper presents methods to measure impedance-based pulse wave velocity in systemic and cerebral vascular systems to study cardiovascular and cerebral parameters in Alzheimer's disease models.

bioRxiv · Jun 22, 2023Physiology

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

B. Shao, M. Killion, A. Oliver, C. Vang, F. Zeleke, K. Neikirk, Z. Vue, E. Garza-Lopez, J.-q. Shao, M. Mungai, J. Lam, Q. Williams, C. Altamura, A. Whiteside, K. Kabugi, , A. Hinton

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

bioRxiv · May 20, 2023Physiology

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

A. Crabtree, K. Neikirk, A. Marshall, L. Vang, D. Stephens, B. Shao, E. Garza-Lopez, J. Lam, B. Rodriguez, M. Mungai, J. Stanley, D. Dean, J. Gaddy, E. Scudese, M. Sweetwyne, , A. Hinton

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

bioRxiv · May 12, 2023Biophysics

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

Z. Vue, E. Garza-Lopez, K. Neikirk, P. Katti, L. Vang, H. K. Beasley, J.-q. Shao, A. G. Marshall, A. Crabtree, A. C. Murphy, B. C. Jenkins, P. Prasad, C. S. Evans, B. T. Taylor, M. Mungai, , Murray

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

bioRxiv · Mar 22, 2022Biophysics