Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome
B. Otvos, T. J. Alban, M. M. Grabowski, D. Bayik, E. E. Mulkearns-Hubert, T. Radivoyevitch, a. Rabljenovic, S. Johnson, C. Androjna, A. M. Mohammadi, G. Barnett, M. S. Ahluwalia, M. A. Vogelbaum, P. E. Fecci, J. D. Lathia
The paper develops a mouse model to study how surgery and steroids affect immune responses in glioblastoma, finding systemic lymphocyte reduction and correlations with tumor growth and patient outcomes.
bioRxiv · Aug 12, 2020Cancer Biology