Author

M. M. Grabowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

D. Bayik· 4 shared M. McGraw· 4 shared B. Otvos· 3 shared J. Lathia· 3 shared M. A. Vogelbaum· 3 shared T. J. Alban· 3 shared A. Rabljenovic· 2 shared B. W. Kristensen· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

D. Bayik

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

K. Kay, J. Lee, E. S. Hong, J. Beilis, S. Dayal, E. R. Wesley, S. Mitchell, S. Z. Wang, D. J. Silver, J. Volovetz, S. Johnson, M. McGraw, M. M. Grabowski, T. Lu, L. Freytag, , J. Lathia

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

bioRxiv · Nov 14, 2023Cancer Biology

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

T. Alban, M. M. Grabowski, B. Otvos, D. B. Watson, A. Zalavadia, V. Makarav, K. M. Troike, M. McGraw, A. Rabljenovic, A. Lauko, C. K. A. Neumann, G. Roversi, K. Waite, G. Cioffi, N. Patil, , J. Lathia

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

bioRxiv · Mar 7, 2022 · PreprintCancer Biology

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

B. Otvos, T. J. Alban, M. M. Grabowski, D. Bayik, E. E. Mulkearns-Hubert, T. Radivoyevitch, a. Rabljenovic, S. Johnson, C. Androjna, A. M. Mohammadi, G. Barnett, M. S. Ahluwalia, M. A. Vogelbaum, P. E. Fecci, J. D. Lathia

The paper develops a mouse model to study how surgery and steroids affect immune responses in glioblastoma, finding systemic lymphocyte reduction and correlations with tumor growth and patient outcomes.

bioRxiv · Aug 12, 2020Cancer Biology

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

D. Bayik, Y. Zhou, C. Park, C. Hong, D. Vail, D. J. Silver, A. J. Lauko, G. A. Roversi, D. C. Watson, A. Lo, T. J. Alban, M. McGraw, M. D. Sorensen, M. M. Grabowski, B. Otvos, , J. Lathia

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

bioRxiv · Feb 19, 2020Immunology

Global immune fingerprinting in glioblastoma reveals immune-suppression signatures associated with prognosis

T. J. Alban, A. G. Alvarado, M. D. Sorensen, D. Bayik, J. Volovetz, E. Serbinowski, E. Mulkearns-Hubert, M. Sinyuk, J. S. Hale, G. R. Onzi, M. McGraw, P. Huang, M. M. Grabowski, C. A. Wathen, T. Radivoyevitch, , J. D. Lathia

The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.

JCI Insight · Nov 2, 2018Peer-reviewedCancer Biology