Cognitive deficits found in a pro-inflammatory state are independent of ERK 1/2 signaling in the murine brain hippocampus treated with Shiga toxin 2 from enterohemorrhagic Escherichia Coli
C. Berdasco, A. Pinto, M. Blake, F. Correa, N. A. Longo Carbajosa, P. A. Geogeghan, A. Cangelosi, M. M. Gironacci, J. Goldstein
This study shows that Stx2 induces cognitive deficits and inflammation in the hippocampus independently of ERK 1/2 signaling, while LPS requires ERK 1/2 for NF-kB activation.
bioRxiv · Aug 24, 2020 · PreprintPathology