Epistasis shapes the fitness landscape of an allosteric specificity switch
K. K. Nishikawa, N. Hoppe, R. Smith, C. Bingman, S. Raman
The paper investigates how epistasis influences the emergence of new inducer specificity in an allosteric transcription factor, revealing nonlinear relationships between local interactions and global function.
bioRxiv · Oct 21, 2020Biochemistry