Author

D. Pagliarini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Jochem· 2 shared A. Reidenbach· 2 shared J. Coon· 2 shared P. Hutchins· 2 shared A. D. Patterson· 1 shared A. Parolia· 1 shared A. Ulbrich· 1 shared B. Chen· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Jochem

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Author profile →

4 papers

Recent·Most cited

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

B. Chen, D. C. Stark, P. V. Jadhav, T. M. Lynn-Nguyen, B. S. Halligan, N. J. Rossiter, N. Sindoni, M. Shin, J. A. Paulo, M. Chang, I. Koo, S. Koshkin, S. Eyunni, P. Ronchi, M. T. Paulsen, , Y. M. Shah

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

bioRxiv · Feb 2, 2024 · PreprintCell Biology

Modifications of lipoic arm by reactive nitrogen species regulate α-ketoacid dehydrogenases

G. L. Seim, Z. Fang, D. Pagliarini, J. Fan

The paper shows reactive nitrogen species modify the lipoic arm of α-ketoacid dehydrogenases, inactivating them in macrophages and affecting mitochondrial metabolism.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry

Multi-omic mitoprotease profiling defines a role for Oct1p in coenzyme Q production

M. Veling, A. Reidenbach, E. Freiberger, N. Kwiecien, P. Hutchins, M. Drahnak, A. Jochem, A. Ulbrich, M. Rush, J. Coon, D. Pagliarini

The paper identifies Oct1p as a mitoprotease that processes Coq5p to enhance coenzyme Q production in yeast.

bioRxiv · Jun 24, 2017Biochemistry

Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient UbiB family

A. Reidenbach, Z. Kemmerer, D. Aydin, A. Jochem, M. McDevitt, P. Hutchins, E. Wilkerson, J. Stark, J. Stefely, I. Johnson, C. Bingman, J. Markley, J. Coon, M. Dal Peraro, D. Pagliarini

This study identifies lipid and small molecule modulators of COQ8, an ancient UbiB family protein, and establishes a chemical genetic system to study its role in CoQ biosynthesis.

bioRxiv · Jun 13, 2017Biochemistry