HIV corruption of the Arp2/3-Cdc42-IQGAP1 axis to hijack cortical F-Actin to promote cell-cell viral spread.
A. Aggarwal, A. Ospina Stella, C. C. Henry, K. Narayan, S. G. Turville
The paper identifies HIV's manipulation of the Arp2/3-Cdc42-IQGAP1 pathway to hijack cortical F-Actin for cell-cell viral spread, showing that this process prevents particle release but enables infection through maturation of contacts.
bioRxiv · Dec 13, 2019Microbiology