Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke
This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.
bioRxiv · Feb 3, 2020Cancer Biology