Author

B. M. Simoes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 1

Frequent Co-Authors

A. Santiago-Gomez· 3 shared S. J. Howell· 3 shared A. H. Sims· 2 shared A. Sarmiento-Castro· 2 shared R. B. Clarke· 2 shared R. Eyre· 2 shared A. Sims· 1 shared B. Kohler· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

A. Santiago-Gomez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

bioRxiv · Feb 3, 2020Cancer Biology

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells

A. Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, M. I. James, A. Santiago-Gomez, R. Eyre, C. Clark, M. E. Brown, M. D. Brooks, D. F. Hayes, M. S. Wicha, S. J. Howell, R. Clarke, B. M. Simoes

The paper identifies a dormant ALDH+IL1R1+ sub-population in anti-estrogen resistant breast cancer stem cells and links IL1R1 expression to treatment failure.

bioRxiv · Oct 29, 2019Cancer Biology

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer

A. Santiago-Gomez, I. Dragoni, R. NicAmhlaoibh, E. Trivier, V. Sabin, B. M. Simoes, J. M. Gee, A. H. Sims, S. J. Howell, R. B. Clarke

This study shows PAK4 promotes stemness and progression in ER+ metastatic breast cancer and that targeting PAK4 reverses endocrine resistance.

bioRxiv · Feb 26, 2019Cancer Biology