Author

R. B. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. H. Sims· 3 shared A. Santiago-Gomez· 2 shared B. M. Simoes· 2 shared S. J. Howell· 2 shared A. Sarmiento-Castro· 1 shared B. Kohler· 1 shared C. Bates· 1 shared C. Chiodo· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

A. H. Sims

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs

M. P. Smith, H. R. Ferguson, J. Ferguson, E. Zindy, K. M. Kowalczyk, T. Kedward, C. Bates, J. Parsons, J. Watson, S. Chandler, P. Fullwood, S. Warwood, D. Knight, R. B. Clarke, C. Francavilla

The paper identifies reciprocal priming between FGFRs and EGFR at recycling endosomes that coordinates signaling outputs in breast cancer cells.

bioRxiv · Jan 4, 2021Cell Biology

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

bioRxiv · Feb 3, 2020Cancer Biology

Targeting endometrial cancer stem cell activity with metformin is inhibited by patient-derived adipocyte-secreted factors

S. J. Kitson, M. Rosser, D. P. Fischer, K. M. Marshall, R. B. Clarke, E. J. Crosbie

This paper shows metformin reduces endometrial cancer stem cell activity, but this effect is blocked by adipocyte-secreted factors from obese patients.

bioRxiv · Feb 28, 2019Cancer Biology

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer

A. Santiago-Gomez, I. Dragoni, R. NicAmhlaoibh, E. Trivier, V. Sabin, B. M. Simoes, J. M. Gee, A. H. Sims, S. J. Howell, R. B. Clarke

This study shows PAK4 promotes stemness and progression in ER+ metastatic breast cancer and that targeting PAK4 reverses endocrine resistance.

bioRxiv · Feb 26, 2019Cancer Biology

The milk protein alpha-casein suppresses triple negative breast cancer stem cell activity via STAT and HIF-1alpha signalling pathways in breast cancer cells and fibroblasts

K. E. Garner, R. Lamb, A. H. Sims, R. B. Clarke

This study shows alpha-casein suppresses triple negative breast cancer stem cell activity through STAT and HIF-1alpha pathways, with clinical data linking high alpha-casein expression to better patient outcomes.

bioRxiv · Feb 21, 2019Cancer Biology