Author

A. Sarmiento-Castro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Santiago-Gomez· 2 shared B. M. Simoes· 2 shared R. Eyre· 2 shared S. J. Howell· 2 shared A. H. Sims· 1 shared A. Sims· 1 shared B. Kohler· 1 shared C. Chiodo· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. Santiago-Gomez

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2 papers

Recent·Most cited

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

B. M. Simoes, A. Santiago-Gomez, C. Chiodo, T. Moreira, D. Conole, S. Lovell, D. Alferez, R. Eyre, K. Spence, A. Sarmiento-Castro, B. Kohler, M. Lanzino, S. Ando, E. Marangoni, A. H. Sims, , R. B. Clarke

This study shows that SFX-01 reduces CSC activity in ER+ breast cancer by inhibiting STAT3 signaling, improving outcomes in endocrine-resistant models.

bioRxiv · Feb 3, 2020Cancer Biology

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells

A. Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, M. I. James, A. Santiago-Gomez, R. Eyre, C. Clark, M. E. Brown, M. D. Brooks, D. F. Hayes, M. S. Wicha, S. J. Howell, R. Clarke, B. M. Simoes

The paper identifies a dormant ALDH+IL1R1+ sub-population in anti-estrogen resistant breast cancer stem cells and links IL1R1 expression to treatment failure.

bioRxiv · Oct 29, 2019Cancer Biology