Author

C. Cigana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Bragonzi· 5 shared D. M. Cirillo· 2 shared F. Sanvito· 2 shared G. Bertoni· 2 shared N. I. Lore'· 2 shared A. Brangonzi· 1 shared A. Colarieti· 1 shared A. Colavolpe· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersMicrobiology

A. Bragonzi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

DeltaF508-Cftr mutation in genetically diverse Collaborative Cross mice yields novel disease-relevant phenotypes for cystic fibrosis

B. Sipione, N. I. Lore, F. Sanvito, G. Rossi, A. Neri, F. Gianferro, S. A. Tascini, A. Livraghi-Butrico, C. Cigana, A. Bragonzi

This study investigates CFTR mutation effects in genetically diverse mice, revealing varied disease phenotypes and highlighting the need for genetic diversity in CF research.

bioRxiv · Jan 31, 2023 · PreprintPathology

Linking CFTR modulators to opportunistic bacterial infections in cystic fibrosis

C. Cigana, R. Giannella, A. Colavolpe, B. Alcalá-Franco, G. Mancini, F. Colombi, C. Bigogno, U. Bastrup, G. Bertoni, A. Bragonzi

This study investigates how CFTR modulators interact with bacterial infections in CF, showing direct antimicrobial effects and enhanced antibiotic activity, while also highlighting the impact of infection on drug exposure.

bioRxiv · Feb 15, 2022Microbiology

NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an anti-virulence target

S. J. Fenn, J.-F. Dubern, C. Cigana, M. D. Simone, J. Lazenby, M. Juhas, S. Schwager, I. Bianconi, G. Döring, J. Elmsley, L. Eberl, P. Williams, A. Brangonzi, M. Camara

This paper identifies PA4130 as a nitrite reductase in Pseudomonas aeruginosa, named NirA, which shows reduced virulence in multiple models and may serve as an anti-virulence target.

bioRxiv · Dec 17, 2020Microbiology

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

S. Ferrara, A. Rossi, S. Ranucci, I. De Fino, A. Bragonzi, C. Cigana, G. Bertoni

This study identifies ErsA as a small RNA that regulates Pseudomonas aeruginosa virulence traits and contributes to host inflammatory responses and antibiotic resistance during chronic infections.

mSphere · Oct 28, 2020Peer-reviewedMicrobiology

A new model of chronic Mycobacterium abscessus lung infection in immunocompetent mice

C. Riva, E. Tortoli, F. Cugnata, F. Sanvito, A. Esposito, M. Rossi, A. Colarieti, T. Canu, C. Cigana, A. Bragonzi, N. I. Lore', P. Miotto, D. M. Cirillo

This study develops a new murine model of chronic Mycobacterium abscessus lung infection and demonstrates its ability to sustain infection and be monitored with MRI.

bioRxiv · Jul 30, 2020Microbiology

The persistence of Nontypeable Haemophilus influenzae fuels airway inflammation

F. Saliu, G. Rizzo, A. Bragonzi, L. Cariani, D. M. Cirillo, C. Colombo, V. Dacco', D. Girelli, S. Rizzetto, S. Barbara, C. Cigana, N. I. Lore'

This study shows that persistent Nontypeable Haemophilus influenzae (NTHi) in CF patients and mice increases inflammation by boosting IL-8, CXCL1, and cytokine levels, and recruiting immune cells.

bioRxiv · May 25, 2020Microbiology