A. Esposito

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development

The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.

4D bioprinted self-folding scaffolds enhance cartilage formation in the engineering of trachea

This study develops a 4D bioprinted self-folding scaffold that enhances cartilage formation in engineered trachea by enabling eCPCs to respond to scaffold curvature.

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells

This study uses polymer physics to model how SARS-CoV-2 infection alters chromatin organization and gene regulation in 4D.

Transcriptomic dissection of Intraepithelial Papillary Mucinous Neoplasms progression by spatial technologies identified novel markers of pancreatic carcinogenesis.

This study uses spatial transcriptomics to identify novel markers and mechanisms of IPMN progression to PDAC, revealing distinct cell clusters and transcription factors associated with different grades of malignancy.

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB

This paper determines the structural basis of mTORC1-dependent phosphorylation of TFEB using cryo-EM, revealing how TFEB is presented to mTORC1 for phosphorylation through a unique RagC GDP-dependent mechanism.

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

The paper shows that continuous IFNα infusion reduces CRC liver metastasis by acting on hepatic endothelial cells to create an antimetastatic vascular barrier.

The biochemical resolving power of fluorescence lifetime imaging: untangling the roles of the instrument response function and photon-statistics

This paper investigates how instrument response function and photon-statistics limit biochemical resolution in fluorescence lifetime microscopy using Fisher information analysis and Monte Carlo simulations.

A new model of chronic Mycobacterium abscessus lung infection in immunocompetent mice

This study develops a new murine model of chronic Mycobacterium abscessus lung infection and demonstrates its ability to sustain infection and be monitored with MRI.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

Comparison of the Hi-C, GAM and SPRITE methods by use of polymer models of chromatin

The paper compares Hi-C, GAM, and SPRITE methods using polymer models of chromatin to assess their accuracy and performance in capturing 3D genomic structures.

Cooperation of partially-transformed clones: an invisible force behind the early stages of carcinogenesis

This study models how cooperation between non- or partially-transformed cells and mutations drives early carcinogenesis through cell-to-cell communication in 3D tissue.

Photon-statistics in sensitized emission FRET and FLIM: a comparative theoretical analysis

The paper analyzes photon-statistics in FRET and FLIM imaging to show how imaging parameters affect precision and provides tools for assay optimization.

Multiplexed biochemical imaging reveals caspase activation patterns underlying single cell fate

This study uses multiplexed biochemical imaging to reveal caspase activation patterns that determine single-cell fate in response to cisplatin, showing non-genetic heterogeneity in cell death mechanisms.

Checkpoint non-fidelity induces a complex landscape of lineage fitness after DNA damage

The paper shows that transient DNA damage with checkpoint non-fidelity leads to varied lineage fitness outcomes in descendant cells, promoting persistence in mutagenic environments.

Enhancing biochemical resolution by hyper-dimensional imaging microscopy

This paper introduces HDIM, a new imaging technique that enhances biochemical resolution in fluorescence microscopy by simultaneously quantifying multiple orthogonal properties of fluorescence emission.

mTOR-dependent phosphorylation controls TFEB nuclear export

This study identifies mTOR-dependent phosphorylation of TFEB as a mechanism controlling its nuclear export and activity during nutrient re-feeding.