L. Eberl

Signal Antagonists Suppress Pseudomonas syringae Pathogenicity

This study designs and synthesizes leudiazen analogs that inhibit Pseudomonas syringae virulence without killing the bacteria, reducing resistance risk.

Functional Biosynthetic Stereodivergence in a Gene Cluster via a Dihydrosydnone N-oxide

The paper investigates a gene cluster that produces both enantiomerically pure and racemic metabolites through a stereodivergent pathway involving a dihydrosydnone N-oxide intermediate.

RNA-Seq reveals that Pseudomonas aeruginosa mounts growth medium-dependent competitive responses when sensing diffusible cues from Burkholderia cenocepacia

This study uses RNA-Seq to show that Pseudomonas aeruginosa adjusts its gene expression based on growth medium and competition signals from Burkholderia cenocepacia.

The structural role of bacterial eDNA in the formation of biofilm streamers

This study shows that extracellular DNA (eDNA) forms the backbone of Pseudomonas aeruginosa biofilm streamers and is essential for their mechanical stability, with exopolysaccharide Pel playing an indirect role.

NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an anti-virulence target

This paper identifies PA4130 as a nitrite reductase in Pseudomonas aeruginosa, named NirA, which shows reduced virulence in multiple models and may serve as an anti-virulence target.

Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide

This study shows that bacterial surface properties, particularly lipopolysaccharide layer integrity, affect the activity of the TAT-RasGAP317-326 antimicrobial peptide against Escherichia coli and Pseudomonas aeruginosa.

A Volatile Signal Controls Virulence in the Plant Pathogen Pseudomonas syringae pv. syringae and a Strategy for Infection Control in Organic Farming

This study identifies leudiazen as a volatile signal molecule in Pseudomonas syringae pv. syringae that controls virulence and demonstrates KMnO4 treatment as a method to degrade it and prevent plant infection.

The effect of flow on swimming bacteria controls the initial colonization of curved surfaces

This study shows that flow conditions control where motile bacteria attach to curved surfaces, with attachment preferentially occurring on leeward sides and downstream of apexes, and increases attachment rates by up to two orders of magnitude compared to non-motile cells.

An investigation of Burkholderia cepacia complex methylomes via SMRT sequencing and mutant analysis

This study investigates DNA methylation in Burkholderia cepacia complex using SMRT sequencing and mutant analysis, revealing its role in genome stability, phage lysogeny, and phenotypic traits.

DNA methylation epigenetically regulates gene expression in Burkholderia cenocepacia

This study shows DNA methylation regulates gene expression in Burkholderia cenocepacia, affecting biofilm formation and motility through specific methyltransferases.

Genetic architecture constrains exploitation of siderophore cooperation in Burkholderia cenocepacia

This study shows that genetic linkage prevents cheating in siderophore cooperation in Burkholderia cenocepacia by linking synthesis and receptor genes, and demonstrates that breaking this linkage allows cheaters to exploit the public good.