Author

C. Coughlan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. W. Graner· 2 shared A. Abosch· 1 shared A. Fringuello· 1 shared A. Graner· 1 shared A. Hilgendorff· 1 shared A. O. Yildirim· 1 shared A. Sengupta· 1 shared B. Ballester Llobell· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

M. W. Graner

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Possible regulation of the immune modulator tetraspanin CD81 by alpha-synuclein in melanoma

N. M. Aloy, C. Coughlan, M. W. Graner, S. N. Witt

The paper investigates how alpha-synuclein regulates CD81 in melanoma, showing their correlation with immune suppression and tumor progression.

bioRxiv · May 9, 2024Cancer Biology

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

M. Wang, A. Graner, B. Knowles, C. McRae, A. Fringuello, P. Paucek, M. Gavrilovic, M. Redwine, C. Coughlan, C. Hanson, B. Metzger, V. Bolus, T. Kopper, M. Smith, W. Zhou, , M. W. Graner

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis

O. Burgy, C. H. Mayr, B. Ballester Llobell, A. Sengupta, D. Schenesse, C. Coughlan, T. Parimon, P. Chen, M. Lindner, A. Hilgendorff, M. Mann, A. O. Yildirim, O. Eickelberg, M. Lehmann, H. B. Schiller, , M. Königshoff

This study identifies fibroblast-derived extracellular vesicles containing SFRP1 that contribute to pulmonary fibrosis and suggests SFRP1 as a therapeutic target.

bioRxiv · Dec 22, 2022Cell Biology