Lfc/Arhgef2 regulates mitotic spindle orientation in hematopoietic stem and progenitor cells and is essential for productive hematopoiesis
D. C. H. Chan, A. Vujovic, J. Xu, V. Gordon, N. Wong, L. P. M. H. de Rooij, C. E. Joyce, J. La Rose, M.-J. Sandi, B. W. Doble, C. D. Novina, R. K. Rottapel, K. J. Hope
This study shows that Lfc/Arhgef2 regulates mitotic spindle orientation in HSCs and is essential for hematopoiesis, as its loss causes impaired hematopoietic recovery and HSC exhaustion.
bioRxiv · Nov 27, 2019Cell Biology