Author

K. J. Hope

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Vujovic· 2 shared D. C. H. Chan· 2 shared J. Xu· 2 shared L. P. M. H. de Rooij· 2 shared N. Wong· 2 shared A. Keyvani Chahi· 1 shared A. Tajik· 1 shared B. W. Doble· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

A. Vujovic

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2 papers

Recent·Most cited

A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target

A. Vujovic, L. P. M. H. de Rooij, A. Keyvani Chahi, H. T. Chen, B. Yee, S. K. Loganathan, L. Liu, D. C. H. Chan, A. Tajik, E. Tsao, S. Moreira, P. Joshi, J. Xu, N. Wong, S. Zandi, , K. J. Hope

This study identifies RNA binding proteins essential for leukemic stem cell survival using an in vivo CRISPR screen and highlights ELAVL1 as a therapeutic target in AML.

bioRxiv · Jun 11, 2022 · PreprintCancer Biology

Lfc/Arhgef2 regulates mitotic spindle orientation in hematopoietic stem and progenitor cells and is essential for productive hematopoiesis

D. C. H. Chan, A. Vujovic, J. Xu, V. Gordon, N. Wong, L. P. M. H. de Rooij, C. E. Joyce, J. La Rose, M.-J. Sandi, B. W. Doble, C. D. Novina, R. K. Rottapel, K. J. Hope

This study shows that Lfc/Arhgef2 regulates mitotic spindle orientation in HSCs and is essential for hematopoiesis, as its loss causes impaired hematopoietic recovery and HSC exhaustion.

bioRxiv · Nov 27, 2019Cell Biology