Author

N. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Vujovic· 2 shared D. C. H. Chan· 2 shared J. Xu· 2 shared K. J. Hope· 2 shared L. P. M. H. de Rooij· 2 shared A. England· 1 shared A. Guerin· 1 shared A. Keyvani Chahi· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A. Vujovic

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

D. Zong, N. C. Koussa, J. A. Cornwell, A. V. Pankajam, M. Kruhlak, N. Wong, R. Chari, S. D. Cappell, A. Nussenzweig

This study maps the cellular response to WRN loss in MSI-H cancers, showing DNA damage accumulation and cell death, and suggests dual targeting of WRN and ATR as a therapeutic strategy.

bioRxiv · Jul 28, 2023Cancer Biology

CNC Knitting Micro-Resolution Mosquito Bite Blocking Textiles

B. Holt, K. Oswalt, A. England, R. Murphy, I. Owens, M. Finney, N. Wong, S. Adhikari, J. McCann, J. F. Beckmann

The paper designs micro-resolution knitted textiles produced by robotic manufacturing to block mosquito bites and protect against vector-borne diseases.

bioRxiv · Apr 21, 2023 · PreprintBioengineering

APLNR marks a cardiac progenitor derived with human induced pluripotent stem cells

Y. Y. Lam, C. H. Chan, L. Geng, N. Wong, W. Keung, Y. F. Cheung

The paper identifies APLNR as a surface marker for cardiac progenitors derived from hiPSCs and shows its utility in isolating and differentiating these progenitors into cardiomyocytes and cardiac mesenchyme.

bioRxiv · Feb 22, 2023Cell Biology

A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target

A. Vujovic, L. P. M. H. de Rooij, A. Keyvani Chahi, H. T. Chen, B. Yee, S. K. Loganathan, L. Liu, D. C. H. Chan, A. Tajik, E. Tsao, S. Moreira, P. Joshi, J. Xu, N. Wong, S. Zandi, , K. J. Hope

This study identifies RNA binding proteins essential for leukemic stem cell survival using an in vivo CRISPR screen and highlights ELAVL1 as a therapeutic target in AML.

bioRxiv · Jun 11, 2022 · PreprintCancer Biology

Cell shape regulates subcellular organelle location to control short-term Ca2+ signal dynamics in vascular smooth muscle cells

R. C. Calizo, M. Bell, A. Ron, M. Hu, S. Bhattacharya, N. Wong, W. G. M. Janssen, G. Perumal, P. Pedersen, S. Scarlata, J. Hone, E. U. Azeloglu, P. Rangamani, R. Iyengar

The paper shows how cell shape changes affect subcellular organelle positioning, altering Ca2+ signaling and phenotypic function in vascular smooth muscle cells.

bioRxiv · Sep 8, 2020 · PreprintCell Biology

PtrR (YneJ) is a novel E. coli transcription factor regulating the putrescine stress response and glutamate utilization

I. A. Rodionova, Y. Gao, A. V. Sastry, J. Monk, n. wong, R. Szubin, H. Lim, Z. Zhang, M. H. Saier, B. O. Palsson

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

bioRxiv · Apr 27, 2020 · PreprintMicrobiology

Lfc/Arhgef2 regulates mitotic spindle orientation in hematopoietic stem and progenitor cells and is essential for productive hematopoiesis

D. C. H. Chan, A. Vujovic, J. Xu, V. Gordon, N. Wong, L. P. M. H. de Rooij, C. E. Joyce, J. La Rose, M.-J. Sandi, B. W. Doble, C. D. Novina, R. K. Rottapel, K. J. Hope

This study shows that Lfc/Arhgef2 regulates mitotic spindle orientation in HSCs and is essential for hematopoiesis, as its loss causes impaired hematopoietic recovery and HSC exhaustion.

bioRxiv · Nov 27, 2019Cell Biology

IRF4 haploinsufficiency in a family with Whipples disease

A. Guerin, G. Kerner, N. Marr, J. G. Markle, F. Fenollar, N. Wong, S. Boughorbel, D. T. Avery, C. Ma, S. Bougarn, M. Bouaziz, V. Beziat, E. Della Mina, T. Lazarovt, L. Worley, , J.-L. Casanova

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.

bioRxiv · Oct 3, 2017Immunology