Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions
Karen Campos-León, Jack Ferguson, Thomas Günther, C. David Wood, Steven Wingett, Selin Pekel, Christy Susan Varghese, Leanne S. Jones, Joanne Stockton, Csilla Várnai, Michelle J. West, Andrew David Beggs, Adam T. Grundhoff, Boris Noyvert, Sally Roberts, Joanna L. Parish
This study shows that HPV18 infection reprograms host transcription by altering CTCF binding and promoter-enhancer interactions, leading to repression of the tumor suppressor CADM1.
PLoS Pathogens · Jan 27, 2025Peer-reviewedMicrobiology