Steven Wingett

The paper identifies an SLC30A9 deletion causing familial medullary thyroid carcinoma through translation reinitiation and shows its oncogenic effects.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

The paper identifies a third mechanism for resolving stalled RNA polymerase II by showing that transcription stalling triggers GSK3-mediated phosphorylation of Ser7 on Pol II, which primes incoming Pol II for efficient elongation.

This study shows that HPV18 infection reprograms host transcription by altering CTCF binding and promoter-enhancer interactions, leading to repression of the tumor suppressor CADM1.

This study identifies histone modification fluctuations as a cause of PSC differentiation bias and presents a chemical chromatin restoration method to reverse it, restoring epiblast-like differentiation potential.

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.

The paper identifies chromatin loop rewiring in adipogenesis and discovers novel regulators and gene-trait associations relevant to obesity and diabetes.

The paper investigates how DNA methylation dynamics during pluripotency exit influence enhancer priming and hematopoietic gene activation in mouse cells.

This study examines how 3D chromatin organization in mouse liver changes throughout the circadian cycle, revealing dynamic domain assignments and promoter-specific chromatin contacts.

This study identifies a neuronal thermostat mechanism in C. elegans that coordinates membrane fluidity across tissues in response to temperature changes.

The paper identifies DNA methylation oscillations as a marker for enhancer classification, showing high predictive power compared to other methods.

The paper introduces Proximity RNA-seq to study nuclear transcriptome organization, revealing bipartite compartments with distinct RNA density and transcription elongation rates.

The paper shows that differential mobility of chromatin segments, influenced by protein occupancy, drives 3D genome organisation in yeast.

The paper identifies autoimmune disease candidate genes by integrating promoter capture Hi-C data with genetic associations in activated CD4+ T cells.

This study uses single-cell Hi-C to analyze chromosomal organization dynamics across the cell cycle, revealing distinct cell cycle-dependent changes in chromosomal compartments, TADs, and loops.