Author

C. Dienemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:virus· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Cramer· 5 shared D. Tegunov· 3 shared H. S. Hillen· 3 shared G. Kokic· 2 shared J. Schmitzova· 2 shared L. Farnung· 2 shared A. Siewert· 1 shared C. Höbartner· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersBiochemistry

P. Cramer

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Author profile →

5 papers

Recent·Most cited

Three-step mechanism of promoter escape by RNA polymerase II

Y. Zhan, F. Grabbe, E. Oberbeckmann, C. Dienemann, P. Cramer

The paper identifies a three-step mechanism for RNA polymerase II promoter escape using in vitro reconstitution and structural analysis.

Molecular Cell · May 1, 2024Peer-reviewedBiochemistry

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F. Kabinger, C. Stiller, J. Schmitzova, C. Dienemann, H. S. Hillen, C. Höbartner, P. Cramer

This paper identifies the molecular mechanism by which molnupiravir induces SARS-CoV-2 RNA mutations through its interaction with the viral RNA-dependent RNA polymerase.

bioRxiv · May 11, 2021Biochemistry

Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

G. Kokic, H. S. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzova, L. Farnung, A. Siewert, C. Hoebartner, P. Cramer

This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.

bioRxiv · Oct 28, 2020Biochemistry

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.7 A inside cells

D. Tegunov, L. Xue, C. Dienemann, P. Cramer, J. Mahamid

The paper introduces a software tool, M, for multi-particle cryo-EM refinement that achieves 3.7 Å resolution of a ribosome-antibiotic complex inside bacterial cells.

bioRxiv · Jun 5, 2020Biophysics

Structure of replicating SARS-CoV-2 polymerase

H. S. Hillen, G. Kokic, L. Farnung, C. Dienemann, D. Tegunov, P. Cramer

This study presents the cryo-EM structure of the SARS-CoV-2 RdRp complex, revealing its mechanism of RNA replication and potential antiviral targets.

bioRxiv · Apr 27, 2020Biophysics