Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir
G. Kokic, H. S. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzova, L. Farnung, A. Siewert, C. Hoebartner, P. Cramer
This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.
bioRxiv · Oct 28, 2020Biochemistry