Author

H. S. Hillen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Dienemann· 3 shared P. Cramer· 3 shared D. Tegunov· 2 shared G. Kokic· 2 shared J. Schmitzova· 2 shared L. Farnung· 2 shared A. Siewert· 1 shared C. Höbartner· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

C. Dienemann

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F. Kabinger, C. Stiller, J. Schmitzova, C. Dienemann, H. S. Hillen, C. Höbartner, P. Cramer

This paper identifies the molecular mechanism by which molnupiravir induces SARS-CoV-2 RNA mutations through its interaction with the viral RNA-dependent RNA polymerase.

bioRxiv · May 11, 2021Biochemistry

Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

G. Kokic, H. S. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzova, L. Farnung, A. Siewert, C. Hoebartner, P. Cramer

This study elucidates how remdesivir inhibits SARS-CoV-2 RNA-dependent RNA polymerase by causing RNA synthesis stalling through a translocation barrier.

bioRxiv · Oct 28, 2020Biochemistry

Structure of replicating SARS-CoV-2 polymerase

H. S. Hillen, G. Kokic, L. Farnung, C. Dienemann, D. Tegunov, P. Cramer

This study presents the cryo-EM structure of the SARS-CoV-2 RdRp complex, revealing its mechanism of RNA replication and potential antiviral targets.

bioRxiv · Apr 27, 2020Biophysics