Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver
The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.
bioRxiv · Nov 30, 2020Biochemistry