Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum
W. Zhan, Y. J. Liu, C. Yang, H. Zhang, J. C. Harris, R. Wang, S. Zhu, J. Sherman, G. Sukenick, A. Rodriguez, H. Deng, C. F. Nathan, L. A. Kirkman, G. Lin
This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.
bioRxiv · Jun 21, 2021 · PreprintMicrobiology