TopBP1 assembles nuclear condensates to switch on ATR signalling.
C. Frattini, A. Promonet, E. Alghoul, S. Vidal Eychenie, M. Lamarque, M.-P. Blanchard, S. Urbach, J. Basbous, A. Constantinou
This study shows TopBP1 forms condensates to activate ATR signaling, which phosphorylates Chk1 and slows replication forks.
bioRxiv · Oct 5, 2020Cell Biology