Author

J. Basbous

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Constantinou· 4 shared E. Alghoul· 2 shared S. Urbach· 2 shared A. Aze· 1 shared A. Barducci· 1 shared A. Carreira· 1 shared A. Promonet· 1 shared A. Pruvost· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

A. Constantinou

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

A. Skobelkina, M. Julien, S. Jeannin, S. Miron, T. Egger, R. Chaaban, G. Bouvignies, R. Ghouil, C. Friel, D. BUSSO, F.-X. Theillet, R. Le Bars, A. Carreira, A. Constantinou, J. Basbous, S. ZINN-JUSTIN

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

bioRxiv · Apr 13, 2024Cell Biology

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

E. Alghoul, M. Paloni, A. Takedachi, S. Urbach, A. Barducci, P.-H. L. Gaillard, J. Basbous, A. Constantinou

This study shows SLX4 forms membraneless compartments that regulate SUMO-RNF4 pathway activity and DNA repair processes.

bioRxiv · Sep 20, 2022Biochemistry

TopBP1 assembles nuclear condensates to switch on ATR signalling.

C. Frattini, A. Promonet, E. Alghoul, S. Vidal Eychenie, M. Lamarque, M.-P. Blanchard, S. Urbach, J. Basbous, A. Constantinou

This study shows TopBP1 forms condensates to activate ATR signaling, which phosphorylates Chk1 and slows replication forks.

bioRxiv · Oct 5, 2020Cell Biology

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.

J. Basbous, A. Aze, L. Chaloin, R. Lebdy, D. Hodroj, C. Ribeyre, M. Larroque, C. Shepard, B. Kim, A. Pruvost, J. Moreaux, D. Maiorano, M. Mechali, A. Constantinou

This study shows dihydropyrimidines are cytotoxic metabolites that cause DNA replication stress and DPCs, suggesting DHP inhibition could target solid tumors.

bioRxiv · Mar 5, 2019Cancer Biology