Tafazzin Mediates Tamoxifen Resistance by Regulating Cellular Phospholipid Composition in ER-Positive Breast Cancer
X. Li, Y. Zhang, T. Zhang, L. Zhao, C. G. Lin, H. Hu, H. Zheng
This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.
bioRxiv · Aug 15, 2023Cancer Biology