Platelet generation from circulating megakaryocytes is triggered in the lung vasculature
X. Zhao, D. Alibhai, T. G. Walsh, N. Tarassova, S. Z. Birol, C. M. Williams, C. R. Neil, E. W. Aitken, A. K. Waller, J. Ballester-Beltran, P. W. Gunning, E. C. Hardeman, E. O. Agbani, I. Hers, C. Ghevaert, A. W. Poole
The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.
bioRxiv · Nov 1, 2021 · PreprintPhysiology