C. M. Williams

Survival of tardigrades (Hypsibius exemplaris) to subzero temperatures depends on exposure intensity, duration, and ice-nucleation--as shown by large-scale mortality dye-based assays

Increased homozygosity due to endogamy results in fitness consequences in a human population

The paper examines the fitness consequences of increased homozygosity in the Himba population, finding a significant association between higher FROH and reduced fertility.

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

This study identifies altered platelet proteome and impaired integrin αIIbβ3 activation in COVID-19 patients, linked to increased platelet-neutrophil aggregates and thromboinflammation.

Receptor-like kinases FER and SRK mediate Lotus japonicus freezing tolerance and climate adaptation

The paper identifies FER and SRK as genes involved in freezing tolerance and climate adaptation in Lotus japonicus.

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

Computer vision approach to characterize size and shape phenotypes of horticultural crops using high-throughput imagery

This paper introduces a computer vision algorithm to quantify shape and size of sweetpotato using high-throughput imagery, achieving 84.59% accuracy in classifying quality grades.

Identification of Human Immune Cell Subtypes Most Vulnerable to IL-1β-induced Inflammatory Signaling Using Mass Cytometry

This study identifies human immune cell subtypes most responsive to IL-1β using mass cytometry, showing that CCR6+ T cells and CD11c mDCs show strong p-NF-κB activation, which is inhibited by Anakinra.

High-throughput determination of the antigen specificities of T cell receptors in single cells

This paper introduces TetTCR-Seq to link TCR sequences to their antigens in single cells and identifies neo-antigen-specific TCRs with no cross-reactivity.