Author

P. W. Gunning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:development & morphogenesis· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. C. Hardeman· 5 shared A. S. Yap· 2 shared J. Begun· 2 shared A. J. Gill· 1 shared A. Johns· 1 shared A. K. Waller· 1 shared A. Mawson· 1 shared A. W. Poole· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCell Biology

E. C. Hardeman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

W. J. Gan, R. Giri, J. Begun, H. Abud, E. C. Hardeman, P. W. Gunning, A. S. Yap, I. Noordstra

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

bioRxiv · Mar 6, 2024Cell Biology

Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

Z. Mann, F. Lim, S. Verma, B. N. Nanavati, J. M. Davies, J. Begun, E. C. Hardeman, P. W. Gunning, D. Subramanyam, A. S. Yap, K. Duszyc

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

bioRxiv · Aug 31, 2023Cell Biology

Specialized actin nanoscale layers control focal adhesion turnover

R. Kumari, K. Ven, M. Chastney, J. Peranen, J. Arron, L. Almeida-Souza, E. Kremneva, R. Poincloux, T. L. Chew, P. W. Gunning, J. Ivaska, P. Lappalainen

The paper identifies two new nanoscale actin layers in focal adhesions, showing their distinct roles in adhesion maturation and disassembly through Tpm1.6 and Tpm3.2.

bioRxiv · Feb 15, 2023 · PreprintCell Biology

Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles

G. M. I. Redpath, J. A. Rae, Y. Yao, J. Ruan, M. L. Cagigas, R. Whan, E. C. Hardeman, P. W. Gunning, V. Ananthanarayanan, R. G. Parton, N. Ariotti

The paper develops a cryo-CLEM workflow using optogenetics to enable rapid in situ structural analysis of organelles without cryo-focused ion beam milling.

bioRxiv · Nov 22, 2022Cell Biology

βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer

J. Kokkinos, G. Sharbeen, R. M. C. Ignacio, E. Pandzic, J. Youkhana, C. Boyer, K. S. Haghighi, M. Gunawarman, D. Goldstein, V. Gebski, M. Pajic, O. Pitiyarachchi, M. E. Davis, G. Schulstad, O. S. M. Arkell, , P. A. Phillips

This study identifies βIII-tubulin as a suppressor of extrinsic apoptosis in pancreatic cancer, showing that its silencing enhances sensitivity to death signals and reduces tumor progression.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

X. Zhao, D. Alibhai, T. G. Walsh, N. Tarassova, S. Z. Birol, C. M. Williams, C. R. Neil, E. W. Aitken, A. K. Waller, J. Ballester-Beltran, P. W. Gunning, E. C. Hardeman, E. O. Agbani, I. Hers, C. Ghevaert, A. W. Poole

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

bioRxiv · Nov 1, 2021 · PreprintPhysiology