Author

E. C. Hardeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 6 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. W. Gunning· 5 shared A. S. Yap· 2 shared J. Begun· 2 shared M. Kavallaris· 2 shared A. Bhardwaj· 1 shared A. J. Gill· 1 shared A. Johns· 1 shared A. K. Waller· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersCell Biology

P. W. Gunning

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Author profile →

8 papers

Recent·Most cited

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

W. J. Gan, R. Giri, J. Begun, H. Abud, E. C. Hardeman, P. W. Gunning, A. S. Yap, I. Noordstra

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

bioRxiv · Mar 6, 2024Cell Biology

Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo

M. Heydecker, A. Shitara, D. Chen, D. Tran, A. Masedunskas, M. Tora, S. Ebrahim, M. A. Appaduray, J. L. Galeano Nino, A. Bhardwaj, K. Narayan, E. C. Hardeman, P. Gunning, R. Weigert

The paper shows how actin filaments dynamically adjust their structure to control membrane transfer between cellular compartments in live rodents.

bioRxiv · Dec 4, 2023 · PreprintCell Biology

Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

Z. Mann, F. Lim, S. Verma, B. N. Nanavati, J. M. Davies, J. Begun, E. C. Hardeman, P. W. Gunning, D. Subramanyam, A. S. Yap, K. Duszyc

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

bioRxiv · Aug 31, 2023Cell Biology

Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles

G. M. I. Redpath, J. A. Rae, Y. Yao, J. Ruan, M. L. Cagigas, R. Whan, E. C. Hardeman, P. W. Gunning, V. Ananthanarayanan, R. G. Parton, N. Ariotti

The paper develops a cryo-CLEM workflow using optogenetics to enable rapid in situ structural analysis of organelles without cryo-focused ion beam milling.

bioRxiv · Nov 22, 2022Cell Biology

βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer

J. Kokkinos, G. Sharbeen, R. M. C. Ignacio, E. Pandzic, J. Youkhana, C. Boyer, K. S. Haghighi, M. Gunawarman, D. Goldstein, V. Gebski, M. Pajic, O. Pitiyarachchi, M. E. Davis, G. Schulstad, O. S. M. Arkell, , P. A. Phillips

This study identifies βIII-tubulin as a suppressor of extrinsic apoptosis in pancreatic cancer, showing that its silencing enhances sensitivity to death signals and reduces tumor progression.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

X. Zhao, D. Alibhai, T. G. Walsh, N. Tarassova, S. Z. Birol, C. M. Williams, C. R. Neil, E. W. Aitken, A. K. Waller, J. Ballester-Beltran, P. W. Gunning, E. C. Hardeman, E. O. Agbani, I. Hers, C. Ghevaert, A. W. Poole

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

bioRxiv · Nov 1, 2021 · PreprintPhysiology

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine.

A. Yeola, S. Subramanian, R. A. Oliver, C. A. Lucas, J. A. I. Thoms, F. Yan, J. Olivier, D. Chacon, M. L. Tursky, T. Hung, C. Power, P. Hardy, D. D. Ma, J. McCarroll, M. Kavallaris, , J. E. Pimanda

This study reprograms human adipocytes into induced multipotent stem cells using PDGF-AB and 5-Azacytidine, showing their ability to regenerate tissues without ectopic growth.

bioRxiv · Jun 4, 2020Cell Biology

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

J. A. Ross, Y. Levy, M. Ripolone, J. S. Kolb, M. Turmaine, M. Holt, M. Moggio, C. Fiorillo, J. Lindqvist, N. Figeac, P. Zammit, H. Jungbluth, J. Vissing, N. Witting, H. Granzier, , J. Ochala

This study identifies nuclear defects in nemaline myopathy caused by impaired contractility and cytoskeletal organisation in muscle fibres.

bioRxiv · Jan 28, 2019Cell Biology