TGFβ drives mitochondrial dysfunction in peripheral blood NK cells during metastatic breast cancer
K. Slattery, V. Zaiatz-Bittencourt, E. Woods, K. Brennan, S. Marks, S. Chew, M. Conroy, C. Goggin, J. Kennedy, D. K. Finlay, C. M. Gardiner
This study shows that TGFβ causes mitochondrial dysfunction in NK cells of metastatic breast cancer patients, and blocking TGFβ improves their metabolic function and IFNγ production.
bioRxiv · Jun 2, 2019 · PreprintImmunology