Author

C. M. Gardiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. Goggin· 1 shared D. Finlay· 1 shared D. K. Finlay· 1 shared D. W. McVicar· 1 shared E. M. Palmieri· 1 shared E. Woods· 1 shared J. F. Walls· 1 shared J. J. Subleski· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

C. Goggin

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2 papers

Recent·Most cited

Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses

J. F. Walls, D. Finlay, D. W. McVicar, C. M. Gardiner, E. M. Palmieri, M. Gonzalez Cotto, J. J. Subleski

This study shows that PKM2's role in NK cell responses is through metabolic regulation and redox status, not transcriptional control.

eLife · Aug 19, 2020Peer-reviewedCell Biology

TGFβ drives mitochondrial dysfunction in peripheral blood NK cells during metastatic breast cancer

K. Slattery, V. Zaiatz-Bittencourt, E. Woods, K. Brennan, S. Marks, S. Chew, M. Conroy, C. Goggin, J. Kennedy, D. K. Finlay, C. M. Gardiner

This study shows that TGFβ causes mitochondrial dysfunction in NK cells of metastatic breast cancer patients, and blocking TGFβ improves their metabolic function and IFNγ production.

bioRxiv · Jun 2, 2019 · PreprintImmunology