Author

J. Bakkers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:zebrafish· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2

Frequent Co-Authors

A. Aharonov· 2 shared A. Shakked· 2 shared E. Tzahor· 2 shared P. D. Nguyen· 2 shared A. Hansen· 1 shared A. I. Isiaku· 1 shared A. J. Wood· 1 shared A. Savidor· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. Aharonov

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Author profile →

5 papers

Recent·Most cited

Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury

A. Shakked, Z. Petrover, A. Aharonov, M. Ghiringhelli, K.-B. Umansky, P. D. Nguyen, D. Kain, J. Elkahal, Y. Divinsky, S. Miyara, G. Friedlander, A. Savidor, L. Zhang, D. Perez, N. Kastan, , E. Tzahor

This study investigates the redifferentiation process in adult mouse hearts after dedifferentiation, finding residual dedifferentiation signatures and protective effects against ischemic injury.

bioRxiv · Feb 22, 2022 · PreprintCell Biology

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model for Phospholamban R14del cardiomyopathy

S. Kamel, C. van Opbergen, L. Koopman, A. Verkerk, Y. Onderwater, C. Polidoro Pontalti, S. Chocron, M. Vos, T. de Boer, T. van Veen, J. Bakkers

The paper uses a zebrafish model to show that istaroxime improves calcium dysregulation and cardiac function in PLN R14del cardiomyopathy.

bioRxiv · Nov 25, 2020Cell Biology

Macrophages provide a transient muscle stem cell niche via NAMPT secretion

D. Ratnayake, P. D. Nguyen, F. J. Rossello, V. C. Wimmer, A. I. Isiaku, L. A. Galvis, A. J. Wood, Z. Julier, T. Boudier, V. Oorschot, K. L. Rogers, M. M. Martino, C. Marcelle, G. J. Lieschke, J. Bakkers, P. D. Currie

The paper identifies macrophages as a transient niche for muscle stem cells through NAMPT secretion, which activates CCR5 on stem cells to drive muscle regeneration.

bioRxiv · Aug 24, 2020Cell Biology

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

H. Honkoop, D. de Bakker, A. Aharonov, F. Kruse, A. Shakked, P. Nguyen, C. de Heus, L. Garric, M. Muraro, A. Shoffner, F. Tessadori, J. Peterson, W. Noort, G. Posthuma, D. Grun, , J. Bakkers

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.

bioRxiv · Dec 18, 2018Cell Biology

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

L. Sala, B. J. van Meer, L. G. J. Tertoolen, J. Bakkers, M. Bellin, R. Davis, C. Denning, M. A. E. Dieben, T. Eschenhagen, E. Giacomelli, C. Grandela, A. Hansen, E. R. Holman, M. R. M. Jongbloed, S. M. Kamel, , F. L. Burton

MUSCLEMOTION quantifies cardiac contraction in vitro and in vivo, providing reliable pharmacological and disease phenotype data across multiple models.

bioRxiv · Jul 8, 2017Physiology