Author

C. H. Douse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

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Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 2 Approach:statistical model· 2 Assay:structural biology· 2

Frequent Co-Authors

Y. Modis· 3 shared I. A. Tchasovnikarova· 2 shared P. J. Lehner· 2 shared R. T. Timms· 2 shared A. Albecka· 1 shared D. M. Prigozhin· 1 shared G. A. Stoll· 1 shared L. E. Farleigh· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

Y. Modis

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Author profile →

3 papers

Recent·Most cited

Structure and functional mapping of the KRAB-KAP1 repressor complex

G. A. Stoll, N. Pandiloski, C. H. Douse, Y. Modis

The paper identifies and validates the molecular interface between KRAB and KAP1, showing its role in TE silencing and gene repression.

bioRxiv · Mar 17, 2022Biochemistry

Periphilin self-association underpins epigenetic silencing by the HUSH complex

D. M. Prigozhin, A. Albecka, C. H. Douse, I. A. Tchasovnikarova, R. T. Timms, L. E. Farleigh, S.-i. Oda, S. M. Freund, S. Maslen, P. J. Lehner, Y. Modis

This study identifies the physicochemical properties of Periphilin required for HUSH complex assembly and epigenetic silencing, showing its N-terminal domain drives aggregation and repressive mark deposition.

bioRxiv · Dec 18, 2019Biochemistry

Neuropathic mutations in MORC2 perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

C. H. Douse, S. Bloor, Y. Liu, M. Shamin, I. A. Tchasovnikarova, R. T. Timms, P. J. Lehner, Y. Modis

This study investigates how neuropathic mutations in MORC2 disrupt dimerization dynamics and epigenetic silencing through structural changes in the ATPase module.

bioRxiv · Oct 2, 2017Biochemistry