Author

R. T. Timms

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. J. Lehner· 3 shared C. H. Douse· 2 shared I. A. Tchasovnikarova· 2 shared Y. Modis· 2 shared A. Albecka· 1 shared A. S. Dickson· 1 shared D. J. van den Boomen· 1 shared D. M. Prigozhin· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

P. J. Lehner

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3 papers

Recent·Most cited

Periphilin self-association underpins epigenetic silencing by the HUSH complex

D. M. Prigozhin, A. Albecka, C. H. Douse, I. A. Tchasovnikarova, R. T. Timms, L. E. Farleigh, S.-i. Oda, S. M. Freund, S. Maslen, P. J. Lehner, Y. Modis

This study identifies the physicochemical properties of Periphilin required for HUSH complex assembly and epigenetic silencing, showing its N-terminal domain drives aggregation and repressive mark deposition.

bioRxiv · Dec 18, 2019Biochemistry

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

N. Volkmar, S. A. Menzies, D. J. van den Boomen, R. T. Timms, A. S. Dickson, J. A. Nathan, P. J. Lehner

This study identifies RNF145 as a sterol-responsive E3 ubiquitin ligase that, along with gp78 and Hrd1, mediates HMGCR degradation in response to sterol levels.

bioRxiv · Aug 14, 2018Cell Biology

Neuropathic mutations in MORC2 perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

C. H. Douse, S. Bloor, Y. Liu, M. Shamin, I. A. Tchasovnikarova, R. T. Timms, P. J. Lehner, Y. Modis

This study investigates how neuropathic mutations in MORC2 disrupt dimerization dynamics and epigenetic silencing through structural changes in the ATPase module.

bioRxiv · Oct 2, 2017Biochemistry