Author

M. Shamin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:structural biology· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. E. Deane· 4 shared S. C. Graham· 4 shared C. M. Jeffries· 2 shared D. I. Svergun· 2 shared E. R. Caroe· 2 shared T. H. Benedyk· 2 shared A. S. A. Mohammed· 1 shared C. H. Douse· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersBiochemistry

J. E. Deane

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Author profile →

5 papers

Recent·Most cited

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

I. M. Hay, M. Shamin, E. R. Caroe, A. S. A. Mohammed, D. I. Svergun, C. M. Jeffries, S. C. Graham, H. J. Sharpe, J. E. Deane

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

bioRxiv · Jun 23, 2022Biochemistry

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

T. H. Benedyk, V. Connor, E. R. Caroe, M. Shamin, D. I. Svergun, J. E. Deane, C. M. Jeffries, C. M. Crump, S. C. Graham

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

bioRxiv · Jun 1, 2022Microbiology

A tetrameric assembly of saposin A: increasing structural diversity in lipid transfer proteins

M. Shamin, S. J. Spratley, S. C. Graham, J. E. Deane

The paper reports the crystal structure of a tetrameric assembly of murine saposin A, revealing structural diversity in lipid transfer proteins.

bioRxiv · Aug 26, 2021Biochemistry

The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading

M. Shamin, T. H. Benedyk, S. C. Graham, J. E. Deane

This study investigates whether Saposin B directly binds CD1d for lipid antigen loading and finds no direct interaction.

bioRxiv · Jul 11, 2019Biochemistry

Neuropathic mutations in MORC2 perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

C. H. Douse, S. Bloor, Y. Liu, M. Shamin, I. A. Tchasovnikarova, R. T. Timms, P. J. Lehner, Y. Modis

This study investigates how neuropathic mutations in MORC2 disrupt dimerization dynamics and epigenetic silencing through structural changes in the ATPase module.

bioRxiv · Oct 2, 2017Biochemistry