Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance
L. S. Rodriguez, C. Pou, L. Tadepally, J. Zhang, C. H. Mugabo, J. Wang, J. Mikes, A. Olin, Y. Chen, J. Rorbach, J.-E. Juto, T.-Q. Li, P. Julin, P. Brodin
This study reports a randomized trial using intranasal mechanical stimulation to reduce ME symptoms by 30% and identifies immune correlates of improvement, suggesting disease tolerance failure as a potential mechanism.
bioRxiv · Feb 20, 2020 · PreprintImmunology