P. Brodin

Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

This study identifies dysregulated antibody-mediated cellular responses in MIS-C, linking NK cell dysfunction to immune pathology and suggesting potential therapeutic interventions.

Plasma membrane order maps functional diversity in immune cells

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

An oxadiazole-based compound potentiates anti- tuberculosis treatment by increasing host resistance via zinc poisoning

The paper identifies oxadiazole-based compounds that enhance anti-tuberculosis treatment by increasing host resistance through zinc poisoning of Mycobacterium tuberculosis.

Scalable in-vitro immunostimulation of human blood for in-depth profiling of acute immune response effects

The paper develops and optimizes an in-vitro medium and mobile incubator for scalable immune stimulation of human blood to enable acute immune response profiling in resource-limited settings.

Molecular Pixelation: Single cell spatial proteomics by sequencing

This paper introduces Molecular Pixelation, a method to quantify protein abundance and spatial distribution in single cells, revealing new patterns in chemokine-stimulated T-cells.

IRG1 controls host responses to restrict Mycobacterium tuberculosis infection

This study shows that IRG1 controls host responses to restrict Mycobacterium tuberculosis infection by modulating immune cell function and limiting bacterial replication.

Data availability of open T-cell receptor repertoire data, a systematic assessment

The paper assesses TCR repertoire data availability across 134 studies and finds 38.1% share raw data, with a significant link between data availability statements and data sharing.

A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

A high content microscopy screening identifies new genes involved in cell width control in Bacillus subtilis

The paper uses high-content microscopy to screen for genes affecting cell width in Bacillus subtilis, identifying 13 mutations, including those related to metabolism.

An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host Cell

This study identifies an Arginine-Rich Motif in the HEV ORF2 capsid protein that regulates its subcellular localization, functionality, and interactions with host cells, revealing its central role in the HEV lifecycle.

Stimulation with mycobacterial glycolipids and PPD reveals different innate immune response profiles in active and latent TB

The paper examines immune response differences between active and latent tuberculosis by analyzing cytokine production in response to Mtb glycolipids and PPD.

Bifidobacteria-mediated immune system imprinting early in life

This study shows that lack of Bifidobacteria in early life is linked to immune dysregulation, and B. infantis EVC001 reduces intestinal Th2 and Th17 responses while promoting Th1 polarization.

Single-cell classification using learned cell phenotypes

The paper introduces a machine learning approach to classify single-cell data by learning from manually curated phenotypes, improving reproducibility and efficiency compared to manual methods.

Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance

This study reports a randomized trial using intranasal mechanical stimulation to reduce ME symptoms by 30% and identifies immune correlates of improvement, suggesting disease tolerance failure as a potential mechanism.

Human immune system variation during one year

This study characterizes longitudinal immune system variation in 99 adults over one year, finding that variability is an individual feature linked to metabolic health markers.

Systems-level immunomonitoring using self-sampled capillary blood

The paper describes a method using self-sampled capillary blood to simplify systems-level immunomonitoring by enabling the detection of immune cell populations and plasma proteins with minimal sample volume.

Cell Generation Dynamics Underlying Naïve T Cell Homeostasis in Adult Humans

This study measures age-related changes in naive T cell turnover using 14C dating and identifies NF-κB signaling as critical for homeostatic proliferation.

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus Is a New Inhibitor of Hepatitis C Virus Replication

This paper identifies dehydrojuncusol, a natural compound from Juncus maritimus, as a new inhibitor of HCV replication that targets NS5A and is effective against DAA-resistant variants.

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus

This study shows that theaflavins from black tea inhibit HCV entry in a dose-dependent manner and show additive effects with existing antivirals.