J. Mikes

Plasma membrane order maps functional diversity in immune cells

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

Scalable in-vitro immunostimulation of human blood for in-depth profiling of acute immune response effects

The paper develops and optimizes an in-vitro medium and mobile incubator for scalable immune stimulation of human blood to enable acute immune response profiling in resource-limited settings.

Bifidobacteria-mediated immune system imprinting early in life

This study shows that lack of Bifidobacteria in early life is linked to immune dysregulation, and B. infantis EVC001 reduces intestinal Th2 and Th17 responses while promoting Th1 polarization.

Single-cell classification using learned cell phenotypes

The paper introduces a machine learning approach to classify single-cell data by learning from manually curated phenotypes, improving reproducibility and efficiency compared to manual methods.

Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance

This study reports a randomized trial using intranasal mechanical stimulation to reduce ME symptoms by 30% and identifies immune correlates of improvement, suggesting disease tolerance failure as a potential mechanism.

Human immune system variation during one year

This study characterizes longitudinal immune system variation in 99 adults over one year, finding that variability is an individual feature linked to metabolic health markers.

Systems-level immunomonitoring using self-sampled capillary blood

The paper describes a method using self-sampled capillary blood to simplify systems-level immunomonitoring by enabling the detection of immune cell populations and plasma proteins with minimal sample volume.