PIP4Ks Suppress Insulin Signaling Through a Catalytic-Independent Mechanism
D. G. Wang, M. N. Paddock, M. R. Lundquist, J. Y. Sun, O. Mashadova, S. Amadiume, T. W. Bumpus, C. Hodakoski, B. D. Hopkins, M. Fine, A. Hill, T. J. Yang, J. M. Baskin, L. E. Dow, L. C. Cantley
This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.
bioRxiv · Jul 20, 2018Cell Biology