Author

O. Mashadova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

L. C. Cantley· 2 shared A. C. Kimmelman· 1 shared A. Hill· 1 shared A. Montalbano· 1 shared A. Myers· 1 shared A. Unni· 1 shared B. D. Hopkins· 1 shared B. N. Nicolay· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

L. C. Cantley

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3 papers

Recent·Most cited

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

J. Ferrarone, J. Thomas, A. Unni, Y. Zheng, M. Nagiec, E. Gardner, O. Mashadova, K. Li, N. Koundouros, A. Montalbano, M. Mustafa, L. Cantley, J. Blenis, N. Sanjana, H. Varmus

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

bioRxiv · Oct 19, 2023 · PreprintCancer Biology

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

B. S. Nelson, L. Lin, D. M. Kremer, C. M. Sousa, C. Cotta-Ramusino, A. Myers, J. Ramos, T. Gao, I. Kovalenko, K. Wilder-Romans, J. Dresser, M. Davis, H.-J. Lee, Z. C. Nwosu, S. Campit, , C. A. Lyssiotis

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

bioRxiv · Jul 25, 2019Cancer Biology

PIP4Ks Suppress Insulin Signaling Through a Catalytic-Independent Mechanism

D. G. Wang, M. N. Paddock, M. R. Lundquist, J. Y. Sun, O. Mashadova, S. Amadiume, T. W. Bumpus, C. Hodakoski, B. D. Hopkins, M. Fine, A. Hill, T. J. Yang, J. M. Baskin, L. E. Dow, L. C. Cantley

This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.

bioRxiv · Jul 20, 2018Cell Biology