L. C. Cantley

Illuminating the Dark Cancer Phosphoproteome Through a Machine-Learned Co-Regulation Map of 26,280 Phosphosites

The paper constructs a co-regulation map of phosphosites using machine learning and phosphoproteomic data, revealing kinase-substrate associations and identifying potential therapeutic targets in cancer.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

The paper models histological transformation of lung cancer and identifies neuroendocrine-specific tolerance to Myc as an oncogenic driver.

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

Epinephrine inhibits PI3K alpha via the Hippo kinases.

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses

The paper examines how SARS-CoV-2 variants interact with host proteases and shows that some proteases remain effective against variant spike proteins.

NAK associated protein 1/NAP1 is required for mitosis and cytokinesis by activating TBK1

This study identifies NAP1 as a critical regulator of TBK1 activation at centrosomes during mitosis and cytokinesis, revealing its role in cell division through substrate interactions and degradation.

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation

This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

Diverse Hotspot Thermal Profiling Methods Detect Phosphorylation-Dependent Changes in Protein Stability

The paper compares two HTP methods, finding that LFE-HTP improves proteoform coverage and detects novel phosphorylation sites affecting protein stability.

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

This study shows coagulation factors like factor Xa and thrombin directly cleave SARS-CoV-2 spike, enhancing viral entry, and suggests anticoagulation could reduce infection.

Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

PIP4Ks Suppress Insulin Signaling Through a Catalytic-Independent Mechanism

This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.