L. E. Dow

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition.

The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.

Solid tumor growth depends on an intricate equilibrium of malignant cell states

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

Oncogenic context shapes the fitness landscape of tumor suppression

The paper models tumor suppression fitness landscapes across four oncogenic contexts and finds context-specific tumor suppressor effects.

Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

This study shows that FTSJ1-mediated tRNASec methylation enhances oxidative stress resistance and metastatic colonization in melanoma.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

This study shows unacylated ghrelin and its analog AZP531 inhibit breast cancer growth in 3D cultures and xenografts by suppressing MAPK signaling and inducing apoptosis.

Lineage reversion drives WNT independence in intestinal cancer

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

GO: A functional reporter system to identify and enrich base editing activity

The paper introduces a functional reporter system called GO to identify and enrich base editing activity in cells with high sensitivity and specificity.

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

A rectal cancer model establishes a platform to study individual responses to chemoradiation

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

PIP4Ks Suppress Insulin Signaling Through a Catalytic-Independent Mechanism

This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.