The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity
C. J. Carnie, M. J. Gotz, C. S. Palma-Chaundler, P. Weickert, A. R. Wanders, A. Serrano-Benitez, H.-Y. Li, V. Gupta, C. J. Blum, M. Sczaniecka-Clift, G. Zagnoli-Vieira, G. D'Alessandro, S. L. Richards, N. Gueorguieva, P. Beli, , S. P. Jackson
This study identifies DCTD and TOPORS as key factors in decitabine cytotoxicity by showing their roles in DPC formation and repair.
bioRxiv · Dec 21, 2023Cell Biology