This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

bioRxiv · Mar 8, 2021 · PreprintBiochemistry

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

J. Wang, M. S. Pavlyukov, D. Yamashita, P. Cheng, Z. Zhang, S.-H. Kim, M. A. Nakano, W. Xie, D. Chen, B. Frett, W.-h. Hu, Y. J. Shin, Y. Lee, V. Goidts, D.-H. Nam, , I. Nakano

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

bioRxiv · Dec 1, 2020 · PreprintCancer Biology

Quantitative three-dimensional nondestructive imaging of whole anaerobic ammonium-oxidizing bacteria

M.-W. Peng, Y. Guan, J.-H. Liu, L. Chen, H. Wang, Z.-Z. Xie, H.-Y. Li, Y.-P. Chen, P. Liu, P. Yan, J.-S. Guo, G. Liu, Y. Shen, F. Fang

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

Journal of Synchrotron Radiation · Apr 17, 2020Peer-reviewedCell Biology

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

C. Shen, L.-L. Zhong, Y. Yang, Y. Doi, D. L. Paterson, N. Stoesser, F. Ma, M. A. E.-G. E.-S. Ahmed, S. Feng, S. Huang, H.-Y. Li, X. Huang, X. Wen, Z. Zhao, M. Lin, , G.-B. Tian

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

bioRxiv · Feb 3, 2020Microbiology