P. Beli

The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity

This study identifies DCTD and TOPORS as key factors in decitabine cytotoxicity by showing their roles in DPC formation and repair.

Direct RNA-binding by MYCN mediates feedback from RNA processing to transcription control

This study shows MYCN binds RNA and regulates transcript turnover, with its RNA-binding activity affecting transcription control through competition with DNA-binding.

The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFs

This study identifies LIS1 and WDR1 as CUL4B-specific DCAFs that bind via phosphorylation, essential for mitosis and brain development, but not the CUL4B-P50L mutant.

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

This study shows that inhibiting HDAC6 with Marbostat-100 reduces MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced B-cell lymphoma.

Nuclear myosin VI maintains replication fork stability

This study shows that nuclear myosin VI stabilizes stalled or reversed replication forks by interacting with WRNIP1 to prevent DNA2-mediated degradation during replication stress.

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

This paper identifies Wnt signaling's role in mitosis by recruiting KIF2A to the spindle, ensuring chromosome congression and alignment in somatic and pluripotent cells.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.