Structural basis of eIF2B-catalyzed GDP exchange and phosphoregulation by the integrated stress response
A. A. Anand, L. R. Kenner, H. C. Nguyen, A. G. Myasnikov, C. J. Klose, L. A. McGeever, J. C. Tsai, L. E. Miller-Vedam, P. Walter, A. Frost
The paper reports cryoEM structures of eIF2 bound to eIF2B, revealing the mechanism of GDP exchange and phosphoregulation in the integrated stress response.
bioRxiv · Dec 22, 2018Biochemistry