An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells
B. L. Jamison, M. Lawrance, C. J. Wang, H. A. DeBerg, D. Sansom, M. A. Gavin, L. S. K. Walker, D. J. Campbell
The paper shows an IL-2 mutein expands regulatory T cells that enhance IL-10 and CTLA-4 to suppress dendritic cells, reducing autoimmunity in NOD mice.
bioRxiv · Dec 1, 2023 · PreprintImmunology